Most of the scientists believe that genetics and environmental factors are involved in the activation of the allergy. Our immunity system, sometime, misinterprets the harmless stuff and tries to expel it out. This misjudgment starts the chemical changes in the body and cause sneezing, sinusitis, coughing, skin rashes, bloating and vomiting.

The body reaction could be devastating and you need an effective allergy medication to minimize the symptoms for the normal body functioning. The allergy even could peril your life as well like in the case of asthma or anaphylaxis.

Though there are many anti-allergy products are available in market but most of them have a short half life of active ingredients and cause drowsiness. Health experts always recommend the allergy products that have non-drowsy effect and provide symptom relief around the clock.

Scientists believe that weak immunity is the underlying cause of the allergy but it is hard to recover and is a long process to reinforce the body immunity system, that is why always avoid the substance that cause allergy to you. Allergies may vary from mild to severe but it is completely a wrong perception that only severe allergies need treatment. Mild allergies, if left untreated, also greatly affect quality of life and your daily routine work.

Allergies sufferers may miss their work, feel exhausted and may not work to their maximum body abilities. With reduced concentration you may put your or others life in danger due to elevated risk of accidents or injury. Untreated allergies can also lead to the complex health issues such as ENT infections, polyps, tonsillitis and so on.

The drugs include Enbrel, Remicade, Humira and Cimzia, act by putting down the immunity system to keep it from attacking the body. The treatment provides relief from painful and swollen joints in patients of rheumatoid arthritis, but it’s “a double-edged sword,” said the FDA’s Dr. Jeffrey Siegel, because these drugs also weaken the body’s defense to multiple infections.

Siegel said the FDA became alarmed after discovering that some doctors have neglected a special kind of fungal infection called histoplasmosis. Around 240 cases of this infection reported to the FDA out of which, 20 percent of patient died.

Investigation starts with a woman case that died because of fungal infection. She was taking one of these drugs. “This case led us to be concerned that there may be other situations in which physicians may not recognize histoplasmosis,” said Siegel.

FDA officials review the agency’s database and found 240 more cases; taking the medications had also developed the fungal infection. Of those, at least 21 appeared to have a late diagnosis and more than half ultimately died.

Siegel said “the FDA’s order Thursday means that the risk of histoplasmosis will be flagged in a black box, the strongest warning information in a drug’s prescribing literature.”

If arthritis patients develop constant fever, cough, fatigue or shortness of breath, which can be signs of the fungal infection. They are recommended to call their doctor immediately.

FDA is also advising doctors to consider use of antifungal drugs in such patients who show these symptoms, even if the infection has not yet been confirmed. Siegel said “such a decision should not be taken lightly, since antifungal drugs can also have dangerous side effects. Doctors should also consider stopping treatment with the immune-suppressing drugs.”

The four drugs belong to TNF-alpha blockers, and are also used for the treatment of Crohn’s disease, juvenile arthritis, certain types of psoriasis, and other conditions. Three of the drugs, Enbrel, Humira and Remicade, are blockbusters and each having a sale of over one billion US dollar annually. Cimzia is newer and less widely used. All are administered by injection.

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