Beta-blocker, time-tested drug used to lower heart rate has been shown to have beneficial effects in patients with myocardial Infarction (MI) and heart failure, but a new research indicates that this is always not the case in patients with high blood pressure.

A critical analysis of nine randomized trials, including almost 70,000 hypertensive patients, illustrates that reduction in heart rate due to beta-blockers, increases the risks of all-cause death, cardiovascular death, MI, stroke, and heart failure (p < 0.0001 for all).

Dr. Franz H. Messerli, from Columbia University, said that “pharmacologically induced bradycardia may lead to dyssynchrony between outgoing and reflected pulse wave, thereby increasing central aortic pressure and the hemodynamic burden to the target organs.”

A total of 22 randomized controlled trials were recognized, of which 9 included heart rate data. All told, 34,096 patients received beta-blockers, 30,139 received other antihypertensive drugs, and 3987 received placebo.

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